Because of resistance, the CDC does not recommend the use of fluoroquinolones for infections acquired in Asia or the Pacific (including Hawaii). In addition, the CDC has stated that it is "probably inadvisable" to use fluoroquinolones for infections acquired in California. Antibiotics for the treatment of gonococcal infection include cefixime (Suprax), ceftriaxone (Rocephin), ciprofloxacin (Cipro), levofloxacin (Levaquin), and ofloxacin (Floxin).
Alternative antibiotics for N. gonorrhoeae infection include spectinomycin, ceftizoxime, cefoxitin (with probenicid), cefotaxime, gatifloxacin, norfloxacin, and lomefloxacin. Since co-infection with C. trachomatis occurs in 10% to 30% of gonococcal urethritis cases, treatment for both infections should be provided. A single 2 g dose of azithromycin treats both gonococcal and chlamydial infection, but this is not recommended by the CDC, presumably because of the significant gastrointestinal side effects. Instead, the CDC recommends combining the regimens for gonococcal and nongonoccal urethrits.